Chapter 02: Pharmacological Principles
Lilley: Pharmacology for Canadian Health Care Practice, 3rd Canadian Edition
1. A patient is receiving two different drugs, which, at their current dose forms and dosages, are
both absorbed into the circulation in identical amounts. Which term best denotes that the
drugs have the same absorption rates?
Two drugs absorbed into the circulation at the same amount (in specific dosage forms) have
the same bioavailability; thus, they are bioequivalent. “Equivalent” is incorrect because the
term “bioavailability” is used to express the extent of drug absorption. “Synergistic” is
incorrect because this term refers to two drugs given together whose resulting effect is greater
than the sum of the effects of each drug given alone. “Compatible” is incorrect because this
term is a general term used to indicate that two substances do not have a chemical reaction
when mixed (or given, in the case of drugs) together.
DIF: Cognitive Level: Comprehension REF: p. 26
2. A patient is receiving medication via intravenous injection. Which information should the
nurse provide for patient education?
a. The medication will cause fewer adverse effects when given intravenously.
b. The medication will be absorbed slowly into the tissues over time.
c. The medication’s action will begin faster when given intravenously.
d. Most of the drug is inactivated by the liver before it reaches the target area.
Intravenous injections are the fastest route of absorption. The intravenous route does not
affect the number of adverse effects, the intravenous route is not a slow route of absorption,
and the intravenous route does not cause inactivation of the drug by the liver before it reaches
the target area.
DIF: Cognitive Level: Comprehension REF: p. 32
3. Which is true regarding parenteral drugs?
a. They bypass the first-pass effect.
b. They decrease blood flow to the stomach.
c. They are altered by the presence of food in the stomach.
d. They exert their effects while circulating in the bloodstream.